Application | Comment | Organism |
---|---|---|
medicine | to study if membrane protein D (PD)-induced protection against NTHI as a vaccine is due to antibodies that inhibit or neutralize its enzymatic activity, a GlpQ enzyme inhibition assay is developed, and serum samples collected from Finnish infants before and after Pnc-PD vaccination are analyzed for enzyme inhibition and anti-PD IgG antibody concentration. Before vaccination at age 2 months, the majority (84%) of infants has no detectable anti-PD IgG antibodies, and all are enzyme inhibition assay negative. At age 13 to 16 months, all infants receiving three or four doses of Pnc-PD have detectable anti-PD IgG antibodies and 36% of the infants receiving three doses and 26% of the infants receiving four doses of Pnc-PD are inhibition assay positive | Haemophilus influenzae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemophilus influenzae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alpha-glycerophosphorylcholine + H2O | - |
Haemophilus influenzae | sn-glycerol 3-phosphate + choline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GlpQ | - |
Haemophilus influenzae |
glycerophosphodiester phosphodiesterase | - |
Haemophilus influenzae |
outer membrane protein D | - |
Haemophilus influenzae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at | Haemophilus influenzae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
assay at | Haemophilus influenzae |