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Literature summary for 3.1.4.45 extracted from

  • Nair, P.; Schaub, B.E.; Huang, K.; Chen, X.; Murphy, R.F.; Griffith, J.M.; Geuze, H.J.; Rohrer, J.
    Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme (2005), J. Cell Sci., 118, 2949-2956.
    View publication on PubMed
Search for more literature for 3.1.4.45

Cloned(Commentary)

Cloned (Comment) Organism
expressed as GFP-fusion protein in HeLa cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E502stop similar localization to the trans Golgi network as the wild-type, lumenal domain of UCE was replaced with monomeric GFP Homo sapiens
Y488A/E493A/E502stop localized to a large extent to the cell surface, lumenal domain of UCE was replaced with monomeric GFP Homo sapiens
Y488A/E502stop localized to a large extent to the cell surface, lumenal domain of UCE was replaced with monomeric GFP Homo sapiens
Y488A/G496A/E497A/E502stop localized to a large extent to the cell surface, lumenal domain of UCE was replaced with monomeric GFP Homo sapiens
Y488A/M494A/E502stop localization shows endosome pattern, not at the cell surface, lumenal domain of UCE was replaced with monomeric GFP Homo sapiens
Y488A/M494A/N495A/E502stop intermediate phenotype, localized to the cell surface and to the trans Golgi network, lumenal domain of UCE was replaced with monomeric GFP Homo sapiens
Y488A/N495A/E502stop localization shows endosome pattern, not at the cell surface, lumenal domain of UCE was replaced with monomeric GFP Homo sapiens
Y488A/P498A/L499A/E502stop localized to a large extent to the cell surface, lumenal domain of UCE was replaced with monomeric GFP Homo sapiens
Y488A/Q492A/E493A/E502stop intermediate phenotype, localized to the cell surface and to the trans Golgi network, lumenal domain of UCE was replaced with monomeric GFP Homo sapiens
Y488A/Q492A/E493A/M494A/N495A/E502stop localization shows endosome pattern and localized to the Golgi, lumenal domain of UCE was replaced with monomeric GFP Homo sapiens
Y488A/Q492A/E502stop similar localization to the trans Golgi network as the wild-type, lumenal domain of UCE was replaced with monomeric GFP Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus in tubulovesicular regions of the trans-Golgi network and in clathrin-coated trans Golgi network vesicles and buds, GFP-fusion protein expressed in HeLa cells, localization of mutants E502stop and Y488A/Q492A/E502stop like wild-type Homo sapiens 5794
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plasma membrane mutants Y488A/Q492A/E493A/E502stop, Y488A/M494A/N495A/E502stop, Y488A/G496A/E497A/E502stop, Y488A/P498A/L499A/E502stop, Y488A/E493A/E502stop Homo sapiens 5886
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Synonyms

Synonyms Comment Organism
UCE uncovering enzyme Homo sapiens