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Literature summary for 3.1.4.41 extracted from

  • Gellings, P.; McGee, D.
    Arcanobacterium haemolyticum phospholipase D enzymatic activity promotes the hemolytic activity of the cholesterol-dependent cytolysin arcanolysin (2018), Toxins, 10, 213 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.41

Protein Variants

Protein Variants Comment Organism
H49A about 65% of wild-type activity Arcanobacterium haemolyticum
N68A about 50% of wild-type activity Arcanobacterium haemolyticum
P43A about 60% of wild-type activity Arcanobacterium haemolyticum
P43A/H49A about 15% of wild-type activity Arcanobacterium haemolyticum
P43A/Y45A about 15% of wild-type activity Arcanobacterium haemolyticum
T275A about 80% of wild-type activity Arcanobacterium haemolyticum
Y45A about 50% of wild-type activity Arcanobacterium haemolyticum
Y45A/H49A about 15% of wild-type activity Arcanobacterium haemolyticum

Organism

Organism UniProt Comment Textmining
Arcanobacterium haemolyticum C7SZ47
-
-
Arcanobacterium haemolyticum DSM 20595 C7SZ47
-
-

General Information

General Information Comment Organism
physiological function the enzymatic activity of phospholipase D is necessary to promote hemolysis by arcanolysin, produced by the human pathogen Arcanobacterium haemolyticum. Incubating phospholipase D with erythrocytes corresponds with an increase in the amount of arcanolysin bound to host membranes Arcanobacterium haemolyticum