Any feedback?
Literature summary for 3.1.4.41 extracted from
- Sphingomyelinase D from Loxosceles laeta venom induces the expression of MMP7 in human keratinocytes contribution to dermonecrosis (2016), PLoS ONE, 11, e0153090 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingomyelin + H2O | Loxosceles laeta | - |
ceramide phosphate + choline | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Loxosceles laeta | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Loxosceles laeta | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingomyelin + H2O | - |
Loxosceles laeta | ceramide phosphate + choline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SMase D | - |
Loxosceles laeta |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in loxoscelism, the enzyme increases the expression/secretion of matrix metalloproteinases MMP2 and MMP9 and also stimulates the expression of MMP7 (matrilysin-1), which is associated with keratinocyte cell death | Loxosceles laeta |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
