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Literature summary for 3.1.4.41 extracted from

  • Lopes, P.H.; Murakami, M.T.; Portaro, F.C.V.; Mesquita Pasqualoto, K.F.; van den Berg, C.; Tambourgi, D.V.
    Targeting Loxosceles spider sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism (2019), J. Enzyme Inhib. Med. Chem., 34, 310-321 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.41

Inhibitors

Inhibitors Comment Organism Structure
4-bromo-N-[(E)-(2-methyl-1H-indol-3-yl)methyleneamino]benzenesulfonamide uncompetitive inhibitor Loxosceles laeta
4-methyl-3-oxo-2-(3-pyridylmethylene)benzo[3,4-b]furan-6-yl 4-chloro-benzenesulfonate mixed-type inhibitor Loxosceles laeta
6-amino-2-((4-cyanobenzyl)thio)pyrimidin-4-yl 4-methylbenzenesulfonate uncompetitive inhibitor Loxosceles laeta

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Loxosceles laeta
-
 ceramide phosphate + choline
-
 ?

Organism

Organism UniProt Comment Textmining
Loxosceles laeta
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Loxosceles laeta
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
 Loxosceles laeta ceramide phosphate + choline
-
 ?

Synonyms

Synonyms Comment Organism
SMase D
-
 Loxosceles laeta
sphingomyelin phosphodiesterase D
-
 Loxosceles laeta

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00049
-
 4-bromo-N-[(E)-(2-methyl-1H-indol-3-yl)methyleneamino]benzenesulfonamide at 37°C, pH not specified in the publication Loxosceles laeta
0.00054
-
 6-amino-2-((4-cyanobenzyl)thio)pyrimidin-4-yl 4-methylbenzenesulfonate at 37°C, pH not specified in the publication Loxosceles laeta
0.00059
-
 4-methyl-3-oxo-2-(3-pyridylmethylene)benzo[3,4-b]furan-6-yl 4-chloro-benzenesulfonate at 37°C, pH not specified in the publication Loxosceles laeta