KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics of enzyme activity on large unilamellar vesicles, overview | Loxosceles laeta |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Loxosceles laeta | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Loxosceles laeta |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-lauroyl-D-erythro-sphingosylphosphorylcholine + H2O | Loxosceles laeta | - |
lauroyl ceramide-1-phosphate + choline | - |
? | |
sphingomyelin + H2O | Loxosceles laeta | - |
ceramide phosphate + choline | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Loxosceles laeta | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Loxosceles laeta | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-lauroyl-D-erythro-sphingosylphosphorylcholine + H2O | - |
Loxosceles laeta | lauroyl ceramide-1-phosphate + choline | - |
? | |
sphingomyelin + H2O | - |
Loxosceles laeta | ceramide phosphate + choline | - |
? | |
sphingomyelin + H2O | from egg yolk | Loxosceles laeta | ceramide phosphate + choline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SMD | - |
Loxosceles laeta |
sphingomyelinase D | - |
Loxosceles laeta |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at | Loxosceles laeta |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Loxosceles laeta |
General Information | Comment | Organism |
---|---|---|
physiological function | the activity of sphingomyelinase D is clearly influenced by the supramolecular organization of its substrate in membranes and, in situ ceramide-1-phosphate generation by enzymatic activity profoundly alters the lateral structure and morphology of the target membranes | Loxosceles laeta |