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Literature summary for 3.1.4.4 extracted from
- Role of phospholipase D in the lifespan of Caenorhabditis elegans (2018), Exp. Mol. Med., 50, 008 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | G5EDU3 | - |
- |
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PLD-1 | - |
Caenorhabditis elegans |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | isoform PLD2 downregulation decreases the transcription of FoxO3a target genes Cu/Zn superoxide dismutase, Mn superoxide dismutase, catalase, thioredoxin-2, and peroxiredoxin-5, whereas ectopic PLD2 expression elevates the mRNA levels of these antioxidant genes | Homo sapiens |
| physiological function | the mRNA level of Pld-1 is inversely correlated with aging. RNAi-mediated knockdown of Pld-1 expression in nematodes enhances reactive oxygen species and lipofuscin accumulation and decreases lifespan, motility, and resistance to stress. Pld-1 knockdown represses the long lifespan of age-1 and akt-1 mutants but does not further reduce the lifespan of daf-16 mutants. The reactive oxygen species scavenger N-acetyl-L-cysteine attenuates the lifespan shortening and age-related biomarkers triggered by pld-1 knockdown. Pld-1 RNAi downregulates the expression of daf-16 target genes such as sod-3, dod-11, and mtl-1 in nematodes | Caenorhabditis elegans |
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