Literature summary for 3.1.4.4 extracted from

Tao, X.; Jia, N.; Cheng, N.; Ren, Y.; Cao, X.; Liu, M.; Wei, D.; Wang, F.Q.
Design and evaluation of a phospholipase D based drug delivery strategy of novel phosphatidyl-prodrug (2017), Biomaterials, 131, 1-14 .

Search for more literature for 3.1.4.4

Application

Application	Comment	Organism
medicine	design of a safe and simple amphiphilic prodrug delivery system, based on the elevated expression of phospholipase D in cancer cells. The method utilizes the transphosphatidylation ability of bacterial PLD on alcohol groups and the hydrolysis activity of overexpressed PLD on phospholipids in cancer cells. Phosphatidyl-doxorubicin is synthesized by bacterial PLD. The prodrug can be selfassembled to nanoparticles with uniform size and doxorubicin can be selectively released in cancer cells triggered by the locally overexpressed PLD. The method can significantly prolong the half-life of doxorubicin in the tumors and decrease the distribution in heart and kidney	Homo sapiens
medicine	design of a safe and simple amphiphilic prodrug delivery system, based on the elevated expression of phospholipase D in cancer cells. The method utilizes the transphosphatidylation ability of bacterial PLD on alcohol groups and the hydrolysis activity of overexpressed PLD on phospholipids in cancer cells. Phosphatidyl-doxorubicin is synthesized by bacterial PLD. The prodrug can be selfassembled to nanoparticles with uniform size and doxorubicin can be selectively released in cancer cells triggered by the locally overexpressed PLD. The method can significantly prolong the half-life of doxorubicin in the tumors and decrease the distribution in heart and kidney	Streptomyces chromofuscus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Streptomyces chromofuscus	Q8KRU5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
doxorubicin + phosphatidate	-	Streptomyces chromofuscus	phosphatidyl-doxorubicin + H2O	-	?
phosphatidyl-doxorubicin + H2O	-	Homo sapiens	doxorubicin + phosphatidate	-	?

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Release 2023.1 (January 2023)