Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.4 extracted from

  • Ma, W.N.; Park, S.Y.; Han, J.S.
    Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic beta cells (2010), Exp. Mol. Med., 42, 456-464.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.4

Cloned(Commentary)

Cloned (Comment) Organism
expression of EGFP-PLD1 in MIN6N8 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information dominant negative PLD1 inhibits glucose-induced Beta2 expression, and glucose-induced insulin secretion is blocked by treatment with 1-butanol or PLD1-siRNA Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MIN6-N8 cell
-
 Homo sapiens
-
pancreatic beta cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
phospholipase D1
-
 Homo sapiens
PLD1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens PLD1 expression is induced by high glucose levels up

General Information

General Information Comment Organism
metabolism high glucose increases insulin secretion through a PLD1-related pathway, high glucose induces the PLD1 binding of Arf6, which is involved in the glucose-induced insulin secretion pathway Homo sapiens
physiological function role of a phospholipase D-related signaling pathway in insulin secretion caused by high glucose in the pancreatic beta-cell line MIN6N8 Homo sapiens