Literature summary for 3.1.4.4 extracted from

Kawasaki, S.; Watanabe, S.; Kimura, S.; Fujita, R.; Ochiai, J.; Sasaki, K.
Regulation of dopamine-induced Na+ current response by small G-protein RhoB or C and phospholipase D in Aplysia neurons (2008), Neurosci. Res., 60, 147-155.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Rho family G-proteins	RhoB or C, but not RhoA, activate PLD. The activation is irreversibly blocked by Clostridium difficile toxin B, an inhibitor for all Rho family G-proteins, or Clostridium botulinum C3 exoenzyme, a specific blocker for RhoA-C, and also by the GAP domain of p50RhoGAP, kinetics, overview	Aplysia kurodai

Inhibitors

Inhibitors	Comment	Organism	Structure
1-butanol	-	Aplysia kurodai
alpha-synuclein	binds to PLD and inhibits its activity, it also markedly depressed the dopamine-induced Na+ current response in vivo	Aplysia kurodai
additional information	either intracellular injection of alpha-synuclein or extracellular application of 1-butanol, inhibitors of PLD, significantly depress the dopamine-induced Na+ current response in neurons	Aplysia kurodai

Organism

Organism	UniProt	Comment	Textmining
Aplysia kurodai	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	from abdominal ganglia	Aplysia kurodai	-

Synonyms

Synonyms	Comment	Organism
PLD	-	Aplysia kurodai

General Information

General Information	Comment	Organism
physiological function	PLD is activated by Rho family G-protein RhoB or C, which facilitates dopamine-induced Na+ current response in neurons, overview	Aplysia kurodai

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Release 2023.1 (January 2023)