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Literature summary for 3.1.4.4 extracted from

  • Mor, A.; Wynne, J.P.; Ahearn, I.M.; Dustin, M.L.; Du, G.; Philips, M.R.
    Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane (2009), Mol. Cell. Biol., 29, 3297-3306.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.4

Cloned(Commentary)

Cloned (Comment) Organism
coexpression of GFP-tagged Rap1 and RFP-tagged PLD1 in COS-1 and HeLa cells showing colocalization is evident on both the plasma membrane and cytoplasmic vesicles Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information PLD1 knockdown in Jurkat cells, silencing PLD1 but not PLD2 expression with shRNA inhibits plasma membrane localization of GFP-Rap1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
n-butanol
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information PLD1 delivery from cytoplasmic vesicles to the plasma membrane requires the catalytic activity of the enzyme Homo sapiens
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-
plasma membrane PLD1 and PLD2 Homo sapiens 5886
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vesicle cytoplasmic vesicles, PLD1 Homo sapiens 31982
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
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T-lymphocyte whereas PLD2 is expressed at the plasma membranes of lymphocytes, PLD1 is expressed on intracellular vesicles. PLD1 resides on the same vesicles as Rap1, is delivered along with Rap1 to the plasma membranes of stimulated T cells, and is required for Rap1 activation and T-cell adhesion Homo sapiens
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Synonyms

Synonyms Comment Organism
phospholipase D1
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 Homo sapiens
PLD type 2
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 Homo sapiens
PLD1
-
 Homo sapiens
PLD2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function PLD1 controls Rap1 trafficking and regulates Rap1 activity, a small GTPase that modulates adhesion of T cells by regulating inside-out signaling through LFA-1, by controlling exocytosis of a stored, vesicular pool of Rap1 that can be activated by C3G upon delivery to the plasma membrane, overview. Inside-out signaling through Rap1 requires PLD1. PLD1 resides on the same vesicles as Rap1, is delivered along with Rap1 to the plasma membranes of stimulated T cells, and is required for Rap1 activation and T-cell adhesion Homo sapiens