Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.4 extracted from

  • Steinhour, E.; Sherwani, S.I.; Mazerik, J.N.; Ciapala, V.; O'Connor Butler, E.; Cruff, J.P.; Magalang, U.; Parthasarathy, S.; Sen, C.K.; Marsh, C.B.; Kuppusamy, P.; Parinandi, N.L.
    Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase (2008), Mol. Cell. Biochem., 315, 97-112.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
L-ascorbic acid activates the lipid signaling enzyme PLD at pharmacological doses, 5 mM, in the bovine lung microvascular endothelial cells, with modulation of PLD activation by phospholipase A2, PLA2. Antioxidants attenuate vitamin C-induced PLA2 , e.g. N-acetylcysteine, propyl gallate, or enzyme catalase activation Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor, the transphosphatidylation reaction is an index of PLD activity in intact cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung microvascular endothelial cells Bos taurus
-
vascular endothelial cell
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 PLD transphosphatidylation activity at different conditions, overview Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor, the transphosphatidylation reaction is an index of PLD activity in intact cells Bos taurus ?
-
 ?

Synonyms

Synonyms Comment Organism
PLD
-
 Bos taurus