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Literature summary for 3.1.4.4 extracted from

  • Cowell, C.F.; Doeppler, H.; Yan, I.K.; Hausser, A.; Umezawa, Y.; Storz, P.
    Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling (2009), J. Cell Sci., 122, 919-928.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
additional information PLD1 is activated by oxidative stress in various cell lines. Reactive oxygen species-induced PLD1 activation involves PKC and tyrosine kinases in various mammalian cell systems Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-butanol
-
 Homo sapiens
additional information inhibition of PLD1 by pharmacological inhibitors blocks PKD1 activation under oxidative stress Homo sapiens
propranolol
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-
mitochondrion
-
 Homo sapiens 5739
-
additional information PLD1 is located at most cellular organelles, including the perinuclear region, mitochondria and the Golgi apparatus Homo sapiens
-
-
perinuclear space
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PLD1 mediates the reactive oxygen species-induced increase in diacylglycerol, which facilitates PKD1 localization to the mitochondria and its activation. Diacylglycerol, to which PKD1 is recruited, is formed downstream of phospholipase D1 and is required for PKD1 localization in the mitochondria and well as activation under oxidative stress, overview. Role for PLD1-induced DAG as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling ?
-
 ?
phosphatidylcholine + H2O Homo sapiens
-
 choline + phosphatidic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
additional information ubiquitous expression of PLD1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PLD1 mediates the reactive oxygen species-induced increase in diacylglycerol, which facilitates PKD1 localization to the mitochondria and its activation. Diacylglycerol, to which PKD1 is recruited, is formed downstream of phospholipase D1 and is required for PKD1 localization in the mitochondria and well as activation under oxidative stress, overview. Role for PLD1-induced DAG as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling Homo sapiens ?
-
 ?
phosphatidylcholine + H2O
-
 Homo sapiens choline + phosphatidic acid
-
 ?

Synonyms

Synonyms Comment Organism
phospholipase D1
-
 Homo sapiens
PLD1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocks PKD1 activation under oxidative stress Homo sapiens
physiological function role for PLD1-induced diacylglycerol as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling, overview Homo sapiens