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Literature summary for 3.1.4.4 extracted from
- Activation of native TRPC3 cation channels by phospholipase D (2010), FASEB J., 24, 318-325.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ARF protein | small G proteins of the Rho and Arf families activate phospholipase D1 | Rattus norvegicus | |
| phosphatidylinositol-4,5-bisphosphate | an essential cofactor for phospholipase D1 activity | Rattus norvegicus |  |
| Rho protein | small G proteins of the Rho and Arf families activate phospholipase D1. Small GTPases might be involved in the activation mechanism of TRPC3 in rat cerebellar Purkinje cells. Rho GTPases can activate phospholipase D1 through two mechanisms: direct binding to phospholipase D1 or activation of phosphatidylinositol-4,5-kinase, which triggers phosphatidylinositol-4,5-bisphosphate production, an essential cofactor for phospholipase D1 activity | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-butanol | does not causes direct inhibition of TRPC3 channels, but causes blocking of phospholipase D which interferes with retrograde signaling, overview. Neither voltage-gated Ca2+-channels nor Ca2+-activated Cl channels are affected by 1-butanol | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | ativation of mGluR1 leads to phospholipase D1 translocation in granule cells, activation of mGluR1 triggers migration and thus activation of PLD1 in a cell-specific manner in the cerebellum | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | phospholipase D activates native TRPC3 cation channels after stimulation of G-protein-coupled type I glutamate receptors in the cerebellum. Small GTPases might be involved in the activation mechanism of TRPC3 in rat cerebellar Purkinje cells, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
isozyme PLD1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| cerebellar Purkinje cell | - |
Rattus norvegicus | - |
| cerebellum | - |
Rattus norvegicus | - |
| granule cell | - |
Rattus norvegicus | - |
| neuron | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | phospholipase D activates native TRPC3 cation channels after stimulation of G-protein-coupled type I glutamate receptors in the cerebellum. Small GTPases might be involved in the activation mechanism of TRPC3 in rat cerebellar Purkinje cells, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phospholipase D1 | - |
Rattus norvegicus |
| PLD-1 | - |
Rattus norvegicus |
| PLD1 | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | key role for phospholipase D in the generation of the slow excitatory postsynaptic current in cerebellar Purkinje cells | Rattus norvegicus |
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