Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphatidylinositol 3,4,5-trisphosphate | activity of PLD1 and PLD2 is highly dependent on the presence of phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate | Mammalia | |
phosphatidylinositol 4,5-bisphosphate | activity of PLD1 and PLD2 is highly dependent on the presence of phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate | Mammalia |
Protein Variants | Comment | Organism |
---|---|---|
additional information | in Drosophila, the absence of PLD is lethal by preventing embryonic cellularization and causes abnormal Golgi apparatus structure and vesicle trafficking | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | - |
Mammalia | 5768 | - |
Golgi apparatus | - |
Drosophila melanogaster | 5794 | - |
Golgi apparatus | - |
Mammalia | 5794 | - |
lysosome | - |
Mammalia | 5764 | - |
membrane | PLD1 and PLD2 exhibit three lipid-binding domains in addition to the active site, a PX domain, a PH domain and a polybasic domain that is responsible for PIP2 stimulated enzyme activity and is sufficient for the membrane recruitment of PLD2. ARF is a PLD1 effector in membrane trafficking, mechanism, detailed overview | Mammalia | 16020 | - |
additional information | PLD1 and PLD2 localize mainly to the plasma membrane and several other organelles, including endosomes, lysosomes, secretory granules and the Golgi apparatus | Mammalia | - |
- |
plasma membrane | - |
Mammalia | 5886 | - |
secretory granule | - |
Mammalia | 30141 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | Drosophila melanogaster | - |
choline + phosphatidate | - |
? | |
phosphatidylcholine + H2O | Mammalia | Regulation and effectors of phospholipase D and phosphatidic acid on the Golgi apparatus, overview | choline + phosphatidate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Mammalia | - |
isozymes PLD1 and PDL2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | - |
Drosophila melanogaster | choline + phosphatidate | - |
? | |
phosphatidylcholine + H2O | - |
Mammalia | choline + phosphatidate | - |
? | |
phosphatidylcholine + H2O | Regulation and effectors of phospholipase D and phosphatidic acid on the Golgi apparatus, overview | Mammalia | choline + phosphatidate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phospholipase D1 | - |
Drosophila melanogaster |
phospholipase D1 | - |
Mammalia |
PLD1 | - |
Mammalia |
PLD2 | - |
Mammalia |
General Information | Comment | Organism |
---|---|---|
metabolism | phospholipase D1 is regulated by ADP-ribosylation factors which are themselves regulators of vesicle trafficking | Drosophila melanogaster |
metabolism | phospholipase D1 is regulated by ADP-ribosylation factors which are themselves regulators of vesicle trafficking | Mammalia |
physiological function | Role of PLD in the production of diacylglycerol, overview. Possible role for PLD in facilitating the fission of vesicles from the trans-Golgi network which are targeted to the embryonic cortex, and it is required for fusion of vesicles into the plasma membrane, overview | Drosophila melanogaster |
physiological function | role of PLD in the production of diacylglycerol, overview. Role of phospholipase D at the Golgi apparatus, overview | Mammalia |