Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.4 extracted from

  • Riebeling, C.; Bourgoin, S.; Shields, D.
    Caspase cleavage of phospholipase D1 in vitro alters its regulation and reveals a novel property of the loop region (2008), Biochim. Biophys. Acta, 1781, 376-382.
    View publication on PubMed
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylinositol 3,4,5-trisphosphate activity of PLD1 and PLD2 is highly dependent on the presence of phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate Mammalia
phosphatidylinositol 4,5-bisphosphate activity of PLD1 and PLD2 is highly dependent on the presence of phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate Mammalia

Protein Variants

Protein Variants Comment Organism
additional information in Drosophila, the absence of PLD is lethal by preventing embryonic cellularization and causes abnormal Golgi apparatus structure and vesicle trafficking Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
 Mammalia 5768
-
Golgi apparatus
-
 Drosophila melanogaster 5794
-
Golgi apparatus
-
 Mammalia 5794
-
lysosome
-
 Mammalia 5764
-
membrane PLD1 and PLD2 exhibit three lipid-binding domains in addition to the active site, a PX domain, a PH domain and a polybasic domain that is responsible for PIP2 stimulated enzyme activity and is sufficient for the membrane recruitment of PLD2. ARF is a PLD1 effector in membrane trafficking, mechanism, detailed overview Mammalia 16020
-
additional information PLD1 and PLD2 localize mainly to the plasma membrane and several other organelles, including endosomes, lysosomes, secretory granules and the Golgi apparatus Mammalia
-
-
plasma membrane
-
 Mammalia 5886
-
secretory granule
-
 Mammalia 30141
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + H2O Drosophila melanogaster
-
 choline + phosphatidate
-
 ?
phosphatidylcholine + H2O Mammalia Regulation and effectors of phospholipase D and phosphatidic acid on the Golgi apparatus, overview choline + phosphatidate
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Mammalia
-
 isozymes PLD1 and PDL2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + H2O
-
 Drosophila melanogaster choline + phosphatidate
-
 ?
phosphatidylcholine + H2O
-
 Mammalia choline + phosphatidate
-
 ?
phosphatidylcholine + H2O Regulation and effectors of phospholipase D and phosphatidic acid on the Golgi apparatus, overview Mammalia choline + phosphatidate
-
 ?

Synonyms

Synonyms Comment Organism
phospholipase D1
-
 Drosophila melanogaster
phospholipase D1
-
 Mammalia
PLD1
-
 Mammalia
PLD2
-
 Mammalia

General Information

General Information Comment Organism
metabolism phospholipase D1 is regulated by ADP-ribosylation factors which are themselves regulators of vesicle trafficking Drosophila melanogaster
metabolism phospholipase D1 is regulated by ADP-ribosylation factors which are themselves regulators of vesicle trafficking Mammalia
physiological function Role of PLD in the production of diacylglycerol, overview. Possible role for PLD in facilitating the fission of vesicles from the trans-Golgi network which are targeted to the embryonic cortex, and it is required for fusion of vesicles into the plasma membrane, overview Drosophila melanogaster
physiological function role of PLD in the production of diacylglycerol, overview. Role of phospholipase D at the Golgi apparatus, overview Mammalia