Activating Compound | Comment | Organism | Structure |
---|---|---|---|
serotonin | i.e. 5-hydroxytryptamine, 5-HT, activates PLD via the 5-HT 2A receptor, leading to the generation of phosphatidic acid that promotes smooth muscle cell proliferation through activations of mammalian target of rapamycin, mTOR, S6K1 and MAPK but not the Rho or PI3-kinase/Akt signaling pathways, overview. Activation is completely blocked by ketanserin | Mus musculus | |
serotonin | i.e. 5-hydroxytryptamine, 5-HT, activates PLD via the 5-HT 2A receptor, leading to the generation of phosphatidic acid that promotes smooth muscle cell proliferation through activations of mammalian target of rapamycin, mTOR, S6K1 and MAPK but not the Rho or PI3-kinase/Akt signaling pathways, overview. Activation is completely blocked by ketanserin | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression of wild-type and inactive mutant PLD1 in bovine pulmonary artery smooth muscle cells | Homo sapiens |
overexpression of wild-type and inactive mutant PLD2 in bovine pulmonary artery smooth muscle cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
K758R | catalytically inactive PLD2 mutant | Mus musculus |
K898R | catalytically inactive PLD1 mutant | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | Mus musculus | - |
choline + phosphatidic acid | - |
? | |
phosphatidylcholine + H2O | Homo sapiens | - |
choline + phosphatidic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes PLD1 and PLD2 | - |
Mus musculus | - |
isozymes PLD1 and PLD2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor leading to formation of phosphatidylbutan-1-ol | Mus musculus | ? | - |
? | |
additional information | PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor leading to formation of phosphatidylbutan-1-ol | Homo sapiens | ? | - |
? | |
phosphatidylcholine + H2O | - |
Mus musculus | choline + phosphatidic acid | - |
? | |
phosphatidylcholine + H2O | - |
Homo sapiens | choline + phosphatidic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PLD | - |
Mus musculus |
PLD | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | phospholipase D signaling is involved in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells. PLD activation participates in the cellular proliferation response to serotonin | Mus musculus |
physiological function | phospholipase D signaling is involved in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells. PLD activation participates in the cellular proliferation response to serotonin | Homo sapiens |