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Literature summary for 3.1.4.4 extracted from

  • Sethu, S.; Mendez-Corao, G.; Melendez, A.J.
    Phospholipase D1 plays a key role in TNF-alpha signaling (2008), J. Immunol., 180, 6027-6034.
    View publication on PubMed
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
TNF-alpha stimulation in a dose-dependent manner Homo sapiens

Application

Application Comment Organism
molecular biology the critical role of PLD1 in the intracellular signaling cascades initiated by TNF-alpha and its functional role for coordinating the signals to inflammatory responses Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information using antisense oligonucleotides to PLD1 and PLD2, respectively, it is shown that TNFalpha stimulates PLD1 and not PLD2. Furthermore, it is shown that PLD1 is required for the activation of sphingosine kinase and cytosolic calcium signals and for NFkappaB and ERK1/2 activation. PLD1 is required for TNF-alpha-induced production of several important cytokines, such as IL-1beta, IL-5, IL-6, and IL-13, in human monocytes Homo sapiens
additional information using antisense oligonucleotides to PLD1 and PLD2, respectively, it is shown that TNFalpha stimulates PLD1 and not PLD2. Furthermore, it is shown that PLD1, and not PLD2, is required for the activation of sphingosine kinase and cytosolic calcium signals and for NFkappaB and ERK1/2 activation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm localisation in resting cells Homo sapiens 5737
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additional information TNF-alpha induces the re-localisation of PLD1, but not PLD2, to the cells periphery Homo sapiens
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-

Organism

Organism UniProt Comment Textmining
Homo sapiens O14939
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-
Homo sapiens Q13393
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-

Source Tissue

Source Tissue Comment Organism Textmining
U-937 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
phospholipase D1
-
 Homo sapiens
phospholipase D2
-
 Homo sapiens
PLD1
-
 Homo sapiens
PLD2
-
 Homo sapiens