Literature summary for 3.1.4.4 extracted from

Nagasaki, A.; Inotsume, K.; Kanada, M.; Uyeda, T.Q.
Phospholipase D is essential for keratocyte-like migration of NBT-II cells (2008), Cell Struct. Funct., 33, 27-33.

Search for more literature for 3.1.4.4

Protein Variants

Protein Variants	Comment	Organism
additional information	depletion of both PLD1 and PLD2 isoenzymes using shRNA reduces the velocity of the migration, but depletion of PLD2 inhibits motility more severly than that of PLD1	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	n-butanol completely blocks the migration of NBT-II cells on collagen-coated substrates and disturbes the characteristic localization of actin along edge of lamellipodia	Rattus norvegicus
n-butanol	n-butanol completely blocks the migration of NBT-II cells on collagen-coated substrates and disturbes the characteristic localization of actin along edge of lamellipodia	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasmic vesicle	using a GFP-PLD1 fusion protein PLD1 localizes intensely to intracellular vesicular compartments in the cell bodies and at zones along the edge of the large lamellipodia	Rattus norvegicus	31410	-
lamellipodium	using a GFP-PLD2 fusion protein PLD2 is localized to the protruding regions of lamellipodia in migrating cells	Rattus norvegicus	30027	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P70496	-	-
Rattus norvegicus	P70498	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
NBT-II cell	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
phospholipase D	-	Rattus norvegicus
PLD1	-	Rattus norvegicus
PLD2	-	Rattus norvegicus

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Release 2023.1 (January 2023)