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Literature summary for 3.1.4.4 extracted from
- Phospholipase D1 is specifically required for regulated secretion of von Willebrand factor from endothelial cells (2009), Blood, 113, 973-980.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| histamine | evokes a transient increase in intraendothelial Ca2+-concentration and enhancey PLD activity significantly. A significant fraction of PLD1 translocates to the plasma membrane after 5 min of histamine stimulation of HUVECs | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| molecular biology | PLD1 and not PLD2 is specifically required for regulated secretion of von Willebrand factor from endothelial cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | reduction of endogenous PLD1 expression using RNAi markedly inhibits the secretion of von Willebrand factor from histamine-stimulated HUVECs. PLD2 knockdown on the other hand shows no effect | Homo sapiens |
| additional information | reduction of endogenous PLD2 shows no effect towards the secretion of von Willebrand factor from histamine-stimulated HUVECs | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the inhibition of PLD-mediated phosphatidic acid production by n-butanol selectively blocks the secretion of von Willebrand factor, but not that of tPA | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| perinuclear space | PLD1 is localized to perinuclear vesicles of resting HUVEC cells | Homo sapiens | - |
- |
| plasma membrane | - |
Homo sapiens | 5886 | - |
| plasma membrane | a significant fraction of PLD1 translocates to the plasma membrane after 5 min of histamine stimulation of HUVECs | Homo sapiens | 5886 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HUVEC cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phospholipase D1 | - |
Homo sapiens |
| phospholipase D2 | - |
Homo sapiens |
| PLD1 | - |
Homo sapiens |
| PLD2 | - |
Homo sapiens |
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