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Literature summary for 3.1.4.4 extracted from

  • Krisanaprakornkit, S.; Chotjumlong, P.; Kongtawelert, P.; Reutrakul, V.
    Involvement of phospholipase D in regulating expression of anti-microbial peptide human beta-defensin-2 (2008), Int. Immunol., 20, 21-29.
    View publication on PubMed
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
Fusobacterium nucleatum cell wall extract stimulation Homo sapiens
phorbol 12-myristate 13-acetate stimulation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-butanol inhibition of enzyme, leading to block of beta-defensin-2 up-regulation by cell wall extract of Fusobacterium nucleatum or phorbol 12-myristate 13-acetate Homo sapiens
ethanol inhibition of enzyme, leading to block of beta-defensin-2 up-regulation by cell wall extract of Fusobacterium nucleatum or phorbol 12-myristate 13-acetate Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens up-regulation of beta-defensin-2 by cell wall extract of Fusobacterium nucleatum or phorbol 12-myristate 13-acetate is mediated by phospholipase D ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HGEC cell human gingival epithelial cell. Constitutive expression of PLD1alpha and PLD1beta splice variants and PLD1 protein, whereas PLD2 is expressed at much lower levels than PLD1 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information up-regulation of beta-defensin-2 by cell wall extract of Fusobacterium nucleatum or phorbol 12-myristate 13-acetate is mediated by phospholipase D Homo sapiens ?
-
 ?