Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | mechanical stimulation of skeletal muscle with intermittent passive stretch ex vivo induces phospholipase D activation, phosphatidic acid accumulation, and signaling by mTOR, i.e. mammalian target of rapamycin | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-butanol | inhibits the mechanically induced increase in phosphatidic acid in skeletal muscle and mechanical activation of signaling by mTOR, i.e. mammalian target of rapamycin | Mus musculus | |
neomycin | inhibits the mechanically induced increase in phosphatidic acid in skeletal muscle | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | mechanical stimuli activate mTOR (mammalian target of rapamycin) signaling through a phospholipase D-dependent increase in phosphatidic acid | ? | - |
? | |
additional information | Mus musculus | mechanical stimuli activate signaling by mTOR, i.e. mammalian target of rapamycin, in skeletal muscle through an enzyme-dependent increase in phosphatidic acid | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | LยดPLD1 and PLD2 are localized to the Z-band in the skeletal muscle, a critical site of mechanical force transmission | Mus musculus | - |
skeletal muscle | isoforms PLD1 and PLD2 are localized to the z-band of skeletal muscle | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | mechanical stimuli activate mTOR (mammalian target of rapamycin) signaling through a phospholipase D-dependent increase in phosphatidic acid | Mus musculus | ? | - |
? | |
additional information | mechanical stimuli activate signaling by mTOR, i.e. mammalian target of rapamycin, in skeletal muscle through an enzyme-dependent increase in phosphatidic acid | Mus musculus | ? | - |
? |