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Literature summary for 3.1.4.4 extracted from

  • Ahn, B.H.; Min, G.; Bae, Y.S.; Min do, S.
    Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells (2006), Exp. Mol. Med., 38, 55-62.
    View publication on PubMed
Search for more literature for 3.1.4.4

Protein Variants

Protein Variants Comment Organism
additional information overexpression of isoforms PLD1 and PLD2, but not their inactive mutants, stimulates Co2+-induced COX-2 expression and prostaglandin E2 production. PLD1 enhances COX-2 expression by Co2+ via reactive oxygen species, p38 MAK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhances Co2+-induced COX-2 expression via reactive oxygen species and p38 MAP kinase, but not PKC-delta, PKA and ERK Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-butanol inhibitor of enzyme. Pretreatment with 1-butanol suppresses Co2+-induced COX-2 expression and prostaglandin E2 formation Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ stimulation of enzyme activity and synthesis of COX-2 protein in time- and dose-dependent manner. Elevated expression of isoforms PLD1 and PLD2 increases hypoxia-induced COX-2 expression and prostaglandin E2 production. PLD1 enhances COX-2 expression by Co2+ via reactive oxygen species, p38 MAK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhances Co2+-induced COX-2 expression via reactive oxygen species and p38 MAP kinase, but not PKC-delta, PKA and ERK Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens protein casein kinase II stimulates basal phospholipase D (PLD1 and PLD2) activity as well as PMA-induced phospholipase D activation in human U87 astroglioma cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens O14939
-
-
Homo sapiens Q13393
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-87MG cell
-
 Homo sapiens
-
U-87MG cell astroglioma cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information protein casein kinase II stimulates basal phospholipase D (PLD1 and PLD2) activity as well as PMA-induced phospholipase D activation in human U87 astroglioma cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PLD1
-
 Homo sapiens
PLD2
-
 Homo sapiens