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Literature summary for 3.1.4.4 extracted from

  • Kurz, T.; Kemken, D.; Mier, K.; Weber, I.; Richardt, G.
    Human cardiac phospholipase D activity is tightly controlled by phosphatidylinositol 4,5-bisphosphate (2004), J. Mol. Cell. Cardiol., 36, 225-232.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylinositol 3,4,5-trisphosphate increases PLD activity Homo sapiens
phosphatidylinositol 4,5-bisphosphate activates Homo sapiens
phosphatidylinositol-3,4,5-trisphosphate with partially purified enzyme, stimulation up to 5fold Homo sapiens
phosphatidylinositol-4,5-bisphosphate in native myocardium, stimulation up to 2fold at 0.1 mM, accompanied by increase in diacylglycerol, with partially purified enzyme, stimulation up to 10fold at 0.1 mM Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
neomycin inhibitory in native myocardium, where phosphatidylinositol-4,5-bisphosphate restores, not inhibitory with partially purified enzyme; inhibits activity in human atrial myocardium, but has no effect on the activity of partially solubilized enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q13393 isozyme PLD1
-

Source Tissue

Source Tissue Comment Organism Textmining
heart atrial myocardium Homo sapiens
-
myocardium
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Homo sapiens
-