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Literature summary for 3.1.4.35 extracted from

  • Yamazaki, A.; Tatsumi, M.; Bondarenko, V.A.; Kurono, S.; Komori, N.; Matsumoto, H.; Matsuura, I.; Hayashi, F.; Yamazaki, R.K.; Usukura, J.
    Mechanism for the regulation of mammalian cGMP phosphodiesterase6. 2: isolation and characterization of the transducin-activated form (2010), Mol. Cell. Biochem., 339, 235-251.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
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Bos taurus 16020
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Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retina
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Bos taurus
-
retinal rod
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Bos taurus
-

Subunits

Subunits Comment Organism
More rod photoreceptor cGMP phosphodiesterase consists of a catalytic subunit complex, Palphabeta, and two inhibitory subunits, Pgamma. Isolation of Palphalphabetagammaagammadelta and Palphabetagammadeltadelta suggests that one C-terminus of Palphabeta is involved in the Palphabetagammagamma interaction with membranes, and that Pgamma dissociation opens another C-terminus for Pdelta, a prenyl-binding protein, binding, which may lead to the expression of high PDE activity. Extraction, isolation and analysis of diverse subunit complexes, detailed overview Bos taurus
tetramer alphabeta(gamma)2 Bos taurus

Synonyms

Synonyms Comment Organism
cGMP phosphodiesterase6
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Bos taurus
PDE6
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Bos taurus

General Information

General Information Comment Organism
evolution mechanisms for PDE activation are similar in mammalian and amphibian photoreceptors as well as in rods and cones Bos taurus
malfunction identification of a Pgamma-depleted PDE as Palphabetagamma, detailed overview Bos taurus