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Literature summary for 3.1.4.35 extracted from

  • Giachini, F.R.; Lima, V.V.; Carneiro, F.S.; Tostes, R.C.; Webb, R.C.
    Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1 (2011), Hypertension, 57, 655-663.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
sildenafil a PDE5 inhibitor, reduces phenylephrine-induced maximal contraction similarly in angiotensin II and control rats Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague-Dawley
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery PDE5 vascular expression is decreased in arteries from angiotensin II hypertensive rats compared to control rats Rattus norvegicus
-
vascular smooth muscle cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanosine 3',5'-cyclic phosphate + H2O
-
 Rattus norvegicus guanosine 5'-phosphate
-
 ?
guanosine 3',5'-cyclic phosphate + H2O
-
 Rattus norvegicus Sprague-Dawley guanosine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PDE5
-
 Rattus norvegicus
phosphodiesterase 5
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus angiotensin II induces PDE5 expression in vitro up

General Information

General Information Comment Organism
malfunction decreasing effect of PDE5 inhibition on vascular contractility, overview Rattus norvegicus