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Literature summary for 3.1.4.35 extracted from

  • Li, M.; Sun, X.; Li, Z.; Liu, Y.
    Inhibition of cGMP phosphodiesterase 5 suppresses serotonin signalling in pulmonary artery smooth muscles cells (2009), Pharmacol. Res., 59, 312-318.
    View publication on PubMed
Search for more literature for 3.1.4.35

Inhibitors

Inhibitors Comment Organism Structure
sildenafil specific PDE5 inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pulmonary artery smooth muscle cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
 Rattus norvegicus 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
cGMP phosphodiesterase 5
-
 Rattus norvegicus
cGMP-specific phosphodiesterase 5
-
 Rattus norvegicus
PDE5
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction enhanced cGMP-dependent protein kinase activity by PDE5 inhibition negatively regulates ERK1/2 activity. PDE5 inhibition suppresses serotonin signalling and consequent cellular proliferation in primary cultured pulmonary artery smooth muscle cells Rattus norvegicus