Literature summary for 3.1.4.35 extracted from

Donato, M.A.; Saraiva, K.L.; Soares e Silva, A.K.; Wanderley, M.I.; Peixoto, C.A.
Follicle development and luteal cell morphology altered by phosphodiesterase-5 inhibitor (2009), Micron, 40, 845-850.

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Application

Application	Comment	Organism
medicine	treatment of mice with vardenafil (5 mg/kg daily for 4 weeks) decreases high density lipoprotein serum levels and the number of antral follicles as well as induces lesser lipid content in luteal cells	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
vardenafil	-	Mus musculus
zaprinast	-	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Mus musculus	5829	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3',5'-cGMP + H2O	Mus musculus	-	5'-GMP	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cGMP + H2O	-	Mus musculus	5'-GMP	-	?

Synonyms

Synonyms	Comment	Organism
PDE5	-	Mus musculus
phosphodiesterase-5	-	Mus musculus

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Release 2023.1 (January 2023)