Application | Comment | Organism |
---|---|---|
medicine | PDE5-inhibitors can improve both lower urinary tract symptoms and erectile dysfunction by targeting various points in the different pathways by increasing cGMP or blocking the effects of norepinephrine and other secondary messengers | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil | - |
Homo sapiens | |
tadalafil | - |
Homo sapiens | |
vardenafil | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | Homo sapiens | - |
5'-GMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bladder | vascular endothelium and muscle fibers only | Homo sapiens | - |
corpus cavernosum penis | - |
Homo sapiens | - |
epididymis | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
vas deferens | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | - |
Homo sapiens | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE5 | - |
Homo sapiens |
phosphodiesterase type 5 | - |
Homo sapiens |