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Literature summary for 3.1.4.35 extracted from

  • Koehler, T.S.; McVary, K.T.
    The relationship between erectile dysfunction and lower urinary tract symptoms and the role of phosphodiesterase type 5 inhibitors (2009), Eur. Urol., 55, 38-48.
    View publication on PubMed

Application

Application Comment Organism
medicine PDE5-inhibitors can improve both lower urinary tract symptoms and erectile dysfunction by targeting various points in the different pathways by increasing cGMP or blocking the effects of norepinephrine and other secondary messengers Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
sildenafil
-
Homo sapiens
tadalafil
-
Homo sapiens
vardenafil
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cGMP + H2O Homo sapiens
-
5'-GMP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder vascular endothelium and muscle fibers only Homo sapiens
-
corpus cavernosum penis
-
Homo sapiens
-
epididymis
-
Homo sapiens
-
kidney
-
Homo sapiens
-
prostate gland
-
Homo sapiens
-
testis
-
Homo sapiens
-
vas deferens
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
Homo sapiens 5'-GMP
-
?

Synonyms

Synonyms Comment Organism
PDE5
-
Homo sapiens
phosphodiesterase type 5
-
Homo sapiens