Application | Comment | Organism |
---|---|---|
medicine | estrogen withdrawal, but not testosterone withdrawal, is a risk factor for PDE5 inhibitor-induced flushing | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil | - |
Mus musculus | |
tadalafil | - |
Mus musculus | |
vardenafil | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | Mus musculus | - |
5'-GMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
artery | in the vasculature, PDE5 is the predominant PDE isoform involved in degrading cGMP | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | - |
Mus musculus | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE5 | - |
Mus musculus |
phosphodiesterase type 5 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the expression levels of PDE5 mRNA in the tail artery are significantly decreased in orchidectomized male mice to 31.8% of the levels in sham-operated male mice | down |