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Literature summary for 3.1.4.35 extracted from
- Effect of the phosphodiesterase 5 inhibitors sildenafil, tadalafil and vardenafil on rat anococcygeus muscle: functional and biochemical aspects (2009), Clin. Exp. Pharmacol. Physiol., 36, 358-366.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | PDE5 inhibitors enhance exogenous and endogenous nitric oxide-mediated relaxation in the rat anococcygeus muscle | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sildenafil | commercial name Viagra | Rattus norvegicus |  |
| tadalafil | commercial name Cialis | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 90000 | 99000 | the antibody against PDE5 recognizes a 90000/99000 Da doublet band, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| anococcygeus muscle | higher expression than in corpus cavernosum | Rattus norvegicus | - |
| corpus cavernosum | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cGMP + H2O | - |
Rattus norvegicus | 5'-GMP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDE5 | - |
Rattus norvegicus |
| phosphodiesterase 5 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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