Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cGMP | allosteric activation | Homo sapiens | |
additional information | protein kinase G-mediated phosphorylation up-regulates activity, PP1 phosphatase-mediated dephosphorylation down-regulates activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil | binding to the active site | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoforms PDE5, three splice variants: PDE5A1, PDE5A2, PDE5A3. Enzyme promoters are sensitive to cGMP or cAMP stimulation | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | protein kinase G-mediated phosphorylation up-regulates activity, PP1 phosphatase-mediated dephosphorylation down-regulates activity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | isoform PDE5 is present in all tissues examined, with heart and cardiomycete being contentious. Splice variants PDE5A1 and PDE5A2 are ubiquitous | Homo sapiens | - |
smooth muscle | splice variant PDE5A3 is specific to smooth muscle | Homo sapiens | - |