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Literature summary for 3.1.4.35 extracted from
- Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1 (2008), Br. J. Pharmacol., 2008, 1-11.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| S-nitrosoglutathione | stimulation of isoform PDE5 phosphorylation and activity, resulting in increased levels of cGMP in gastric smooth muscle cells. Concurrent activation of cells with acetylcholine augments stimulation and attenuates cGMP levels | Oryctolagus cuniculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
isoform PDE5 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | activation of isoform PDE5 by phosphorylation. PDE5 is dephosphorylated by the catalytic subunit of protein phosphatase 1 but not protein phosphatase 2A | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| stomach | - |
Oryctolagus cuniculus | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | isoform PDE5 is associated with protein phosphatase 1 | Oryctolagus cuniculus |
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