Literature summary for 3.1.4.35 extracted from

Xiong, Y.; Lu, H.T.; Li, Y.; Yang, G.F.; Zhan, C.G.
Characterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations (2006), Biophys. J., 91, 1858-1867.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular dynamics simulations based on crystal structure PDB code 1RKP. The second bridging ligand in the active site is HO- rather than H2O, serving as a nucleophile to initialize the catalytic hydrolysis of cGMP	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O76074	isoform PDE5A	-

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Release 2023.1 (January 2023)