Literature summary for 3.1.4.35 extracted from

Blount, M.A.; Beasley, A.; Zoraghi, R.; Sekhar, K.R.; Bessay, E.P.; Francis, S.H.; Corbin, J.D.
Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation (2004), Mol. Pharmacol., 66, 144-152.

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Inhibitors

Inhibitors	Comment	Organism	Structure
sildenafil	IC50: 3.7 nM	Bos taurus
tadalafil	IC50: 1.8 nM	Bos taurus
vardenafil	IC50: 0.091 nM	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Bos taurus	-

Synonyms

Synonyms	Comment	Organism
PDE5	-	Bos taurus
phosphodiesterase-5	-	Bos taurus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000000091	-	IC50: 0.091 nM	Bos taurus	vardenafil
0.0000018	-	IC50: 1.8 nM	Bos taurus	tadalafil
0.0000037	-	IC50: 3.7 nM	Bos taurus	sildenafil

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Release 2023.1 (January 2023)