Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Pseudomonas aeruginosa | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Pseudomonas aeruginosa | PlcHR2 is a secreted toxin that exhibits phospholipase C and sphingomyelinase activities. It shows hydrolytic activity of PlcHR2 on bilayers of varying lipid compositions, e.g. on giant unilamellar vesicles composed of sphingomyelin, phosphatidylcholine, phosphatidylethanolamine, and cholesterol | ? | - |
? | |
phosphatidylcholine + H2O | Pseudomonas aeruginosa | - |
1,2-sn-diacylglycerol + phosphocholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PlcHR2 is a secreted toxin that exhibits phospholipase C and sphingomyelinase activities. It shows hydrolytic activity of PlcHR2 on bilayers of varying lipid compositions, e.g. on giant unilamellar vesicles composed of sphingomyelin, phosphatidylcholine, phosphatidylethanolamine, and cholesterol | Pseudomonas aeruginosa | ? | - |
? | |
phosphatidylcholine + H2O | - |
Pseudomonas aeruginosa | 1,2-sn-diacylglycerol + phosphocholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phospholipase C/sphingomyelinase | - |
Pseudomonas aeruginosa |
phospholipase C/sphingomyelinase HR2 | - |
Pseudomonas aeruginosa |
PlcHR2 | - |
Pseudomonas aeruginosa |
General Information | Comment | Organism |
---|---|---|
additional information | enzyme binding to lipid vesicles is a slow, cooperative process, but after the initial cluster of bound enzyme molecules further binding and catalytic activity follows rapidly. At some late stage of enzyme activity, apparently three-dimensional structures or lipidic aggregates are formed which marks another burst of enzyme activity, and the lysis of the giant vesicle | Pseudomonas aeruginosa |
physiological function | the enzyme's end-product 1,2-sn-diacylglycerol has an important effect on the bilayer architecture of the lipid membranes/lipid vesicles | Pseudomonas aeruginosa |