Any feedback?
Literature summary for 3.1.4.3 extracted from
- Characterization of two distinct phospholipase C enzymes from Burkholderia pseudomallei (2007), Microbiology, 153, 1907-1915.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | isoform Plc-1 inactivation mutant shows decreased extracellular enzyme activity. Plc-1 has no effect on plaque-forming efficinecy, but increases the efficiency of isoform Plc-2 to form plaques | Burkholderia pseudomallei |
| more | | isoform Plc-2 inactivation mutant shows decreased extracellular enzyme activity. Plc-2 is involved in plaque formationand has a significant role in host cell cytotoxicity | Burkholderia pseudomallei |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Burkholderia pseudomallei | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 77000 | - |
x * 77000, calculated | Burkholderia pseudomallei |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Burkholderia pseudomallei | enzyme is not haemolytic for human erythrocytes and not involved in multinucleated giant cell formation or induction of apoptotic cell death | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Burkholderia pseudomallei | Q9RGS8 | isoform Plc-1 | - |
| Burkholderia pseudomallei | Q9RGS8 | isoform Plc-2 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | sequence shows a mature polypeptide of 700 amino acids plus a signal peptide of 34 amino acids | Burkholderia pseudomallei |
| proteolytic modification | sequence shows a mature polypeptide of 705 amino acids plus a signal peptide of 35 amino acids | Burkholderia pseudomallei |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme is not haemolytic for human erythrocytes and not involved in multinucleated giant cell formation or induction of apoptotic cell death | Burkholderia pseudomallei | ? | - |
? | |
| phosphatidylcholine + H2O | - |
Burkholderia pseudomallei | 1,2-diacylglycerol + phosphorylcholine | - |
? | |
| sphingomyelin + H2O | - |
Burkholderia pseudomallei | ceramide + phosphorylcholine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 77000, calculated | Burkholderia pseudomallei |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Burkholderia pseudomallei | calculated | - |
6 |
| Burkholderia pseudomallei | calculated | - |
6.2 |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
