Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | Mus musculus | - |
5'-GMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q922S4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyocyte cell line | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | - |
Mus musculus | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE2A | - |
Mus musculus |
phosphodiesterase 2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | blockade of isoform PDE2 promotes cGMP signaling to offset the pathogenesis of experimental heart failure (induced by pressure overload or sympathetic hyperactivation), reversing the development of left ventricular hypertrophy, compromised contractility, and cardiac fibrosis | Mus musculus |