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Literature summary for 3.1.4.17 extracted from

  • Patel, N.S.; Klett, J.; Pilarzyk, K.; Lee, D.I.; Kass, D.; Menniti, F.S.; Kelly, M.P.
    Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span (2018), Neurobiol. Aging, 65, 217-234 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.17

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol PDE9A localizes to the cytosol in the bladder Mus musculus 5829
-
cytosol PDE9A localizes to the cytosol in the bladder Homo sapiens 5829
-
membrane PDE9A localizes to the membrane in all organs except the bladder Mus musculus 16020
-
membrane PDE9A localizes to the membrane in all organs except the bladder Homo sapiens 16020
-
nucleus PDE9A localizes to the nucleus in the brain Mus musculus 5634
-
nucleus PDE9A localizes to the nucleus in the brain Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cAMP + H2O Mus musculus
-
 5'-AMP
-
 ?
3',5'-cAMP + H2O Homo sapiens
-
 5'-AMP
-
 ?
3',5'-cGMP + H2O Mus musculus highest affinity for 3',5'-cGMP 5'-GMP
-
 ?
3',5'-cGMP + H2O Homo sapiens highest affinity for 3',5'-cGMP 5'-GMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Homo sapiens
-
brain cortex cell line
-
 Mus musculus
-
brain cortex cell line
-
 Homo sapiens
-
cerebellum
-
 Mus musculus
-
cerebellum
-
 Homo sapiens
-
hippocampus
-
 Mus musculus
-
hippocampus
-
 Homo sapiens
-
lung
-
 Mus musculus
-
lung
-
 Homo sapiens
-
Purkinje layer
-
 Mus musculus
-
Purkinje layer
-
 Homo sapiens
-
striatum
-
 Mus musculus
-
striatum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Mus musculus 5'-AMP
-
 ?
3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?
3',5'-cGMP + H2O highest affinity for 3',5'-cGMP Mus musculus 5'-GMP
-
 ?
3',5'-cGMP + H2O highest affinity for 3',5'-cGMP Homo sapiens 5'-GMP
-
 ?

Subunits

Subunits Comment Organism
? x * 100000, isoform PDE9X-100, SDS-PAGE Mus musculus
? x * 100000, isoform PDE9X-100, SDS-PAGE Homo sapiens
? x * 120000, isoform PDE9X-120, SDS-PAGE Mus musculus
? x * 120000, isoform PDE9X-120, SDS-PAGE Homo sapiens
? x * 175000, isoform PDE9X-175, SDS-PAGE Mus musculus
? x * 175000, isoform PDE9X-175, SDS-PAGE Homo sapiens
? x * 50000, isoform PDE9A6, SDS-PAGE Mus musculus
? x * 50000, isoform PDE9A6, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
3',5'-cyclic nucleotide phosphodiesterase
-
 Mus musculus
3',5'-cyclic nucleotide phosphodiesterase
-
 Homo sapiens
PDE9A6 isoform Mus musculus
PDE9A6 isoform Homo sapiens
PDE9X-100 isoform Mus musculus
PDE9X-100 isoform Homo sapiens
PDE9X-120 isoform Mus musculus
PDE9X-120 isoform Homo sapiens
PDE9X-175 isoform Mus musculus
PDE9X-175 isoform Homo sapiens

Expression

Organism Comment Expression
Mus musculus enzyme mRNA expression/localization dramatically changes across neurodevelopment down
Homo sapiens PDE9A mRNA is elevated in the aged human hippocampus with dementia when there is a history of traumatic brain injury up