Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Corynebacterium glutamicum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.23 | - |
3',5'-cGMP | apparent value, at pH 7.5 and 30°C | Corynebacterium glutamicum | |
2.54 | - |
3',5'-cAMP | apparent value, at pH 7.5 and 30°C | Corynebacterium glutamicum |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | contains 2.8 zinc atoms per molecule of purified enzyme | Corynebacterium glutamicum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | Corynebacterium glutamicum | - |
5'-AMP | - |
? | |
3',5'-cAMP + H2O | Corynebacterium glutamicum ATCC 13032 | - |
5'-AMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Corynebacterium glutamicum | - |
- |
- |
Corynebacterium glutamicum ATCC 13032 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography and Superdex 200 gel filtration | Corynebacterium glutamicum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Corynebacterium glutamicum | 5'-AMP | - |
? | |
3',5'-cAMP + H2O | - |
Corynebacterium glutamicum ATCC 13032 | 5'-AMP | - |
? | |
3',5'-cGMP + H2O | - |
Corynebacterium glutamicum | 5'-GMP | - |
? | |
3',5'-cGMP + H2O | - |
Corynebacterium glutamicum ATCC 13032 | 5'-GMP | - |
? | |
bis-(4-nitrophenyl) phosphate + H2O | - |
Corynebacterium glutamicum | 4-nitrophenyl phosphate + 4-nitrophenol | - |
? | |
bis-(4-nitrophenyl) phosphate + H2O | - |
Corynebacterium glutamicum ATCC 13032 | 4-nitrophenyl phosphate + 4-nitrophenol | - |
? | |
additional information | the enzyme is unable to dephosphorylate 5'-AMP | Corynebacterium glutamicum | ? | - |
? | |
additional information | the enzyme is unable to dephosphorylate 5'-AMP | Corynebacterium glutamicum ATCC 13032 | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer or tetramer | gel filtration | Corynebacterium glutamicum |
Synonyms | Comment | Organism |
---|---|---|
cAMP phosphodiesterase | - |
Corynebacterium glutamicum |
cAMP-PDE | - |
Corynebacterium glutamicum |
cg2761 | - |
Corynebacterium glutamicum |
CpdA | - |
Corynebacterium glutamicum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
65 | 70 | - |
Corynebacterium glutamicum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
18.1 | - |
3',5'-cAMP | apparent value, at pH 7.5 and 30°C | Corynebacterium glutamicum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | 7 | - |
Corynebacterium glutamicum |
General Information | Comment | Organism |
---|---|---|
malfunction | a deletion mutant shows a 2fold increased cAMP level on D-glucose and reduced growth rates on carbon sources | Corynebacterium glutamicum |
physiological function | the enzyme plays a key role in the control of the cellular cAMP concentration and transcriptional regulator GlxR activity and is crucial for optimal metabolism and growth of Corynebacterium glutamicum | Corynebacterium glutamicum |