Activating Compound | Comment | Organism | Structure |
---|---|---|---|
clozapine | chronic treatment with 20 mg/kg clozapine increases PDE10A expression by 62% | Rattus norvegicus | |
haloperidol | chronic treatment with 1 mg/kg haloperidol increases PDE10A expression by 118% | Rattus norvegicus | |
haloperidol | chronic treatment with 1 mg/kg haloperidol increases PDE10A expression by 65% | Rattus norvegicus | |
additional information | not influenced by treatment with clozapine | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in COS-1 cells | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | PDE1B is found almost exclusively in the cytosolic fraction | Rattus norvegicus | 5829 | - |
membrane | PDE10A is found almost exclusively in the membrane fraction | Rattus norvegicus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
SDS-PAGE | Rattus norvegicus |
74000 | - |
SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
corpus striatum | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Rattus norvegicus | 5'-AMP | - |
? | |
3',5'-cGMP + H2O | - |
Rattus norvegicus | 5'-GMP | - |
? | |
nucleoside 3',5'-cyclic phosphate + H2O | - |
Rattus norvegicus | nucleoside 5'-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE10A | - |
Rattus norvegicus |
PDE1B | - |
Rattus norvegicus |
phosphodiesterase-10A | - |
Rattus norvegicus |
phosphodiesterase-1B | - |
Rattus norvegicus |