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Literature summary for 3.1.4.17 extracted from

  • Dlaboga, D.; Hajjhussein, H.; ODonnell, J.M.
    Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum (2008), Neuropharmacology, 54, 745-754.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
clozapine chronic treatment with 20 mg/kg clozapine increases PDE10A expression by 62% Rattus norvegicus
haloperidol chronic treatment with 1 mg/kg haloperidol increases PDE10A expression by 118% Rattus norvegicus
haloperidol chronic treatment with 1 mg/kg haloperidol increases PDE10A expression by 65% Rattus norvegicus
additional information not influenced by treatment with clozapine Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-1 cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol PDE1B is found almost exclusively in the cytosolic fraction Rattus norvegicus 5829
-
membrane PDE10A is found almost exclusively in the membrane fraction Rattus norvegicus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
SDS-PAGE Rattus norvegicus
74000
-
SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
corpus striatum
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
Rattus norvegicus 5'-AMP
-
?
3',5'-cGMP + H2O
-
Rattus norvegicus 5'-GMP
-
?
nucleoside 3',5'-cyclic phosphate + H2O
-
Rattus norvegicus nucleoside 5'-phosphate
-
?

Synonyms

Synonyms Comment Organism
PDE10A
-
Rattus norvegicus
PDE1B
-
Rattus norvegicus
phosphodiesterase-10A
-
Rattus norvegicus
phosphodiesterase-1B
-
Rattus norvegicus