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Literature summary for 3.1.4.16 extracted from
- Purification and properties of cyclic phosphodiesterase: 3-nucleotidase, a periplasmic enzyme of Haemophilus influenzae (1972), Arch. Biochem. Biophys., 153, 837-844.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2'-AMP | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae |  |
| 3'-AMP | cleavage of 2',3'-cyclic nucleotides | Haemophilus influenzae | |
| 5'-AMP | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| periplasm | - |
Haemophilus influenzae | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | stimulates cleavage of di-p-nitrophenyl phosphate | Haemophilus influenzae | |
| Co2+ | stimulates cleavage of dis-p-nitrophenyl phosphate | Haemophilus influenzae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Haemophilus influenzae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Haemophilus influenzae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Haemophilus influenzae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-AMP + H2O | - |
Haemophilus influenzae | adenosine + phosphate | - |
? | |
| 3'-CMP + H2O | - |
Haemophilus influenzae | cytidine + phosphate | - |
? | |
| 3'-GMP + H2O | - |
Haemophilus influenzae | guanosine + phosphate | - |
? | |
| cyclic 2',3'-CMP + H2O | - |
Haemophilus influenzae | 3'-CMP | - |
? | |
| cyclic 2',3'-GMP + H2O | - |
Haemophilus influenzae | 3'-GMP | - |
? | |
| cyclic 2',3'-UMP + H2O | - |
Haemophilus influenzae | 3'-UMP | - |
? | |
| di-p-nitrophenyl phosphate + H2O | - |
Haemophilus influenzae | p-nitrophenol + p-nitrophenyl phosphate | - |
? | |
| additional information | 3'-nucleotidase and 5'-nucleotidase activity resides in the same protein | Haemophilus influenzae | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.6 | 6.4 | hydrolysis of di-p-nitrophenyl phosphate | Haemophilus influenzae |
| 7.2 | 7.8 | hydrolysis of 3'-AMP | Haemophilus influenzae |
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