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Literature summary for 3.1.4.12 extracted from

  • Xiong, Z.J.; Huang, J.; Poda, G.; Pomes, R.; Prive, G.G.
    Structure of human acid sphingomyelinase reveals the role of the saposin domain in activating substrate hydrolysis (2016), J. Mol. Biol., 428, 3026-3042 .
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme with a a built-in N-terminal saposin domain does not require an external saposin activator protein Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
vapor diffusion method, using 0.2 M sodium acetate, 20% (w/v) polyethylene glycol 8000, 0.1 M sodium cacodylate, pH 6.0 Homo sapiens

Protein Variants

Protein Variants Comment Organism
D278A inactive Homo sapiens
H319Y inactive Homo sapiens
H425R inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ binuclear zinc center Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Homo sapiens
-
ceramide + phosphocholine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P17405
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, HiTrap phenyl column chromatography, Q-Sepharose column chromatography, and Superdex 200 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens ceramide + phosphocholine
-
?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Homo sapiens
ASM
-
Homo sapiens
SMPD1
-
Homo sapiens