Activating Compound | Comment | Organism | Structure |
---|---|---|---|
C2 toxin | activates acid but not neutral sphingomyelinase | Bacillus cereus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amitriptyline | - |
Bacillus cereus | |
bromoenol lactone | - |
Bacillus cereus | |
imipramine | - |
Bacillus cereus | |
additional information | not inhibited by GW4869 | Bacillus cereus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | Bacillus cereus | - |
ceramide + phosphocholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus cereus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Bacillus cereus | ceramide + phosphocholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid sphingomyelinase | - |
Bacillus cereus |
aSMase | - |
Bacillus cereus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockdown reduces Clostridium botulinum C2 toxin-induced cell rounding | Bacillus cereus |
physiological function | Clostridium botulinum C2 toxin requires acid sphingomyelinase activity during internalization into cells | Bacillus cereus |