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Literature summary for 3.1.4.12 extracted from

  • Nagahama, M.; Takehara, M.; Takagishi, T.; Seike, S.; Miyamoto, K.; Kobayashi, K.
    Cellular uptake of Clostridium botulinum C2 toxin requires acid sphingomyelinase activity (2017), Infect. Immun., 85, e00966-16 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
C2 toxin activates acid but not neutral sphingomyelinase Bacillus cereus

Inhibitors

Inhibitors Comment Organism Structure
amitriptyline
-
Bacillus cereus
bromoenol lactone
-
Bacillus cereus
imipramine
-
Bacillus cereus
additional information not inhibited by GW4869 Bacillus cereus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Bacillus cereus
-
ceramide + phosphocholine
-
?

Organism

Organism UniProt Comment Textmining
Bacillus cereus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Bacillus cereus ceramide + phosphocholine
-
?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Bacillus cereus
aSMase
-
Bacillus cereus

General Information

General Information Comment Organism
malfunction enzyme knockdown reduces Clostridium botulinum C2 toxin-induced cell rounding Bacillus cereus
physiological function Clostridium botulinum C2 toxin requires acid sphingomyelinase activity during internalization into cells Bacillus cereus