Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ES048 | when tested in splenocyte extracts, ES048 specifically inhibits enzyme activity up to a concentration of 0.002 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
lymph node | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-hexadecanoylamino-4-methylumbelliferyl-phosphorylcholine + H2O | - |
Homo sapiens | 6-hexadecanoylamino-4-methylumbelliferone + phosphorylcholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutral sphingomyelinase | - |
Homo sapiens |
NSM | - |
Homo sapiens |
SMase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme ablation reduces cell polarity | Homo sapiens |
physiological function | the enzyme activity is important in T cell recruitment and directional migration. The enzyme is highly important in directional T cell motility in response to SDF1-alpha | Homo sapiens |