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Literature summary for 3.1.4.12 extracted from

  • Collenburg, L.; Beyersdorf, N.; Wiese, T.; Arenz, C.; Saied, E.M.; Becker-Flegler, K.A.; Schneider-Schaulies, S.; Avota, E.
    The activity of the neutral sphingomyelinase is important in T cell recruitment and directional migration (2017), Front. Immunol., 8, 1007 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
ES048 when tested in splenocyte extracts, ES048 specifically inhibits enzyme activity up to a concentration of 0.002 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-
lymph node
-
Homo sapiens
-
spleen
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-hexadecanoylamino-4-methylumbelliferyl-phosphorylcholine + H2O
-
Homo sapiens 6-hexadecanoylamino-4-methylumbelliferone + phosphorylcholine
-
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Synonyms

Synonyms Comment Organism
neutral sphingomyelinase
-
Homo sapiens
NSM
-
Homo sapiens
SMase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme ablation reduces cell polarity Homo sapiens
physiological function the enzyme activity is important in T cell recruitment and directional migration. The enzyme is highly important in directional T cell motility in response to SDF1-alpha Homo sapiens