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Literature summary for 3.1.4.12 extracted from

  • Klutzny, S.; Lesche, R.; Keck, M.; Kaulfuss, S.; Schlicker, A.; Christian, S.; Sperl, C.; Neuhaus, R.; Mowat, J.; Steckel, M.; Riefke, B.; Prechtl, S.; Parczyk, K.; Steigemann, P.
    Functional inhibition of acid sphingomyelinase by fluphenazine triggers hypoxia-specific tumor cell death (2017), Cell Death Dis., 8, e2709 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
fluphenazine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Homo sapiens
-
ceramide + phosphocholine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BODIPY FL C12-sphingomyelin + H2O
-
Homo sapiens BODIPY FL C12-ceramide + phosphocholine
-
?
sphingomyelin + H2O
-
Homo sapiens ceramide + phosphocholine
-
?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Homo sapiens
aSMase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction acid sphingomyelinase inhibition causes cellular sphingomyelin accumulation, which induces cancer cell death specifically in hypoxic tumor spheroids Homo sapiens