Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amitriptyline | specific inhibitor | Homo sapiens | |
imipramine | specific inhibitor | Homo sapiens | |
L-carnitine | specific inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
helper T-lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Homo sapiens | ceramide + phosphocholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid sphingomyelinase | - |
Homo sapiens |
ASM | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition blocks T-helper cell responses. Enzyme knockdown dampens CD3/CD28 signals and broadly inhibits T-helper cell responses | Homo sapiens |
physiological function | the enzyme mediates T-cell proliferation after anti-CD3/CD28 antibody stimulation and alters CD4+ T-cell activation signals by generating ceramide | Homo sapiens |