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Literature summary for 3.1.4.12 extracted from

  • Bai, A.; Kokkotou, E.; Zheng, Y.; Robson, S.C.
    Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses (2015), Cell Death Dis., 6, e1828 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
amitriptyline specific inhibitor Homo sapiens
imipramine specific inhibitor Homo sapiens
L-carnitine specific inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
helper T-lymphocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens ceramide + phosphocholine
-
?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Homo sapiens
ASM
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme inhibition blocks T-helper cell responses. Enzyme knockdown dampens CD3/CD28 signals and broadly inhibits T-helper cell responses Homo sapiens
physiological function the enzyme mediates T-cell proliferation after anti-CD3/CD28 antibody stimulation and alters CD4+ T-cell activation signals by generating ceramide Homo sapiens