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BRENDA support

Literature summary for 3.1.4.12 extracted from

  • Supinski, G.S.; Alimov, A.P.; Wang, L.; Song, X.H.; Callahan, L.A.
    Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation (2015), Am. J. Physiol. Lung Cell Mol. Physiol., 309, L614-L624 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
GW4869
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
-
Mus musculus
-
skeletal muscle
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
neutral sphingomyelinase 2
-
Mus musculus
nSMase2
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus addition of tumor necrosis factor-alpha, interleukin-1beta, interferon-gamma, and lipopolysaccharide to C2C12 cells elicits significant increases in enzyme activity levels up

General Information

General Information Comment Organism
physiological function neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation. Enzyme activation is required for the development of infection-induced diaphragm calpain activation and muscle weakness Mus musculus