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Literature summary for 3.1.4.12 extracted from

  • Rhein, C.; Tripal, P.; Seebahn, A.; Konrad, A.; Kramer, M.; Nagel, C.; Kemper, J.; Bode, J.; Muehle, C.; Gulbins, E.; Reichel, M.; Becker, C.M.; Kornhuber, J.
    Functional implications of novel human acid sphingomyelinase splice variants (2012), PLoS ONE, 7, e35467.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene SMPD1, splicing form ASM-5, genetic organisation of splicing variants, overview. Alternative splicing of the enzyme of functional significance for the cellular stress response, possibly representing a mechanism for maintaining constant levels of cellular ASM enzyme activity. Expression of FLAG-tagged ASM-5 in HeLa cells Homo sapiens
gene SMPD1, splicing form ASM-6, genetic organisation of splicing variants, overview. Alternative splicing of the enzyme of functional significance for the cellular stress response, possibly representing a mechanism for maintaining constant levels of cellular ASM enzyme activity. Expression of FLAG-tagged ASM-6 in HeLa cells Homo sapiens
gene SMPD1, splicing form ASM-7, genetic organisation of splicing variants, overview. Alternative splicing of the enzyme of functional significance for the cellular stress response, possibly representing a mechanism for maintaining constant levels of cellular ASM enzyme activity. Expression of FLAG-tagged ASM-7 in HeLa cells Homo sapiens
splicing forms ASM-1 to ASM-4, genetic organisation of splicing variants, overview. Alternative splicing of the enzyme of functional significance for the cellular stress response, possibly representing a mechanism for maintaining constant levels of cellular ASM enzyme activity. Expression of FLAG-tagged ASM-1 in HeLa cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
x * 45000, about, sequence calculation Homo sapiens
56000
-
x * 56000, about, sequence calculation Homo sapiens
67000
-
x * 67000, about, sequence calculation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a sphingomyelin + H2O Homo sapiens
-
a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Organism

Organism UniProt Comment Textmining
Homo sapiens E9LUE7 acid sphingomyelinase, splicing form ASM-5; gene SMPD1
-
Homo sapiens E9LUE8 acid sphingomyelinase, splicing form ASM-6; gene SMPD1
-
Homo sapiens E9LUE9 acid sphingomyelinase, splicing form ASM-7; gene SMPD1
-
Homo sapiens P17405 acid sphingomyelinase, splicing forms ASM-1 to ASM-4; gene SMPD1
-

Source Tissue

Source Tissue Comment Organism Textmining
brain splicing form ASM-4 Homo sapiens
-
additional information ubiquitous tissue distribution of enzyme, distribution of splicing forms, overview Homo sapiens
-
neuroglioma cell
-
Homo sapiens
-
peripheral blood mononuclear cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a sphingomyelin + H2O
-
Homo sapiens a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?
a sphingomyelin + H2O using radiolabelled C12-sphingomyelin as substrate Homo sapiens a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Subunits

Subunits Comment Organism
? x * 45000, about, sequence calculation Homo sapiens
? x * 56000, about, sequence calculation Homo sapiens
? x * 67000, about, sequence calculation Homo sapiens

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Homo sapiens
ASM
-
Homo sapiens

General Information

General Information Comment Organism
malfunction mediates a variety of stress-related cellular processes. The pathological effects of dysregulated acid sphingomyelinase activity are evident in several human diseases and indicate an important functional role for acid sphingomyelinase regulation. Alternative splicing of acid sphingomyelinase is of functional significance for the cellular stress response, possibly representing a mechanism for maintaining constant levels of cellular enzyme activity Homo sapiens