Cloned (Comment) | Organism |
---|---|
gene SMPD1, splicing form ASM-5, genetic organisation of splicing variants, overview. Alternative splicing of the enzyme of functional significance for the cellular stress response, possibly representing a mechanism for maintaining constant levels of cellular ASM enzyme activity. Expression of FLAG-tagged ASM-5 in HeLa cells | Homo sapiens |
gene SMPD1, splicing form ASM-6, genetic organisation of splicing variants, overview. Alternative splicing of the enzyme of functional significance for the cellular stress response, possibly representing a mechanism for maintaining constant levels of cellular ASM enzyme activity. Expression of FLAG-tagged ASM-6 in HeLa cells | Homo sapiens |
gene SMPD1, splicing form ASM-7, genetic organisation of splicing variants, overview. Alternative splicing of the enzyme of functional significance for the cellular stress response, possibly representing a mechanism for maintaining constant levels of cellular ASM enzyme activity. Expression of FLAG-tagged ASM-7 in HeLa cells | Homo sapiens |
splicing forms ASM-1 to ASM-4, genetic organisation of splicing variants, overview. Alternative splicing of the enzyme of functional significance for the cellular stress response, possibly representing a mechanism for maintaining constant levels of cellular ASM enzyme activity. Expression of FLAG-tagged ASM-1 in HeLa cells | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
x * 45000, about, sequence calculation | Homo sapiens |
56000 | - |
x * 56000, about, sequence calculation | Homo sapiens |
67000 | - |
x * 67000, about, sequence calculation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a sphingomyelin + H2O | Homo sapiens | - |
a ceramide + phosphocholine | a ceramide is an N-acylsphingosine | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | E9LUE7 | acid sphingomyelinase, splicing form ASM-5; gene SMPD1 | - |
Homo sapiens | E9LUE8 | acid sphingomyelinase, splicing form ASM-6; gene SMPD1 | - |
Homo sapiens | E9LUE9 | acid sphingomyelinase, splicing form ASM-7; gene SMPD1 | - |
Homo sapiens | P17405 | acid sphingomyelinase, splicing forms ASM-1 to ASM-4; gene SMPD1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | splicing form ASM-4 | Homo sapiens | - |
additional information | ubiquitous tissue distribution of enzyme, distribution of splicing forms, overview | Homo sapiens | - |
neuroglioma cell | - |
Homo sapiens | - |
peripheral blood mononuclear cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a sphingomyelin + H2O | - |
Homo sapiens | a ceramide + phosphocholine | a ceramide is an N-acylsphingosine | ? | |
a sphingomyelin + H2O | using radiolabelled C12-sphingomyelin as substrate | Homo sapiens | a ceramide + phosphocholine | a ceramide is an N-acylsphingosine | ? |
Subunits | Comment | Organism |
---|---|---|
? | x * 45000, about, sequence calculation | Homo sapiens |
? | x * 56000, about, sequence calculation | Homo sapiens |
? | x * 67000, about, sequence calculation | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
acid sphingomyelinase | - |
Homo sapiens |
ASM | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | mediates a variety of stress-related cellular processes. The pathological effects of dysregulated acid sphingomyelinase activity are evident in several human diseases and indicate an important functional role for acid sphingomyelinase regulation. Alternative splicing of acid sphingomyelinase is of functional significance for the cellular stress response, possibly representing a mechanism for maintaining constant levels of cellular enzyme activity | Homo sapiens |