Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a sphingomyelin + H2O | Homo sapiens | - |
a ceramide + phosphocholine | a ceramide is an N-acylsphingosine, ceramide colocalizes with acetylated tubulin in primary cilia and the mitotic spindle of human embryonic stem cells | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic stem cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a sphingomyelin + H2O | - |
Homo sapiens | a ceramide + phosphocholine | a ceramide is an N-acylsphingosine | ? | |
a sphingomyelin + H2O | - |
Homo sapiens | a ceramide + phosphocholine | a ceramide is an N-acylsphingosine, ceramide colocalizes with acetylated tubulin in primary cilia and the mitotic spindle of human embryonic stem cells | ? |
Synonyms | Comment | Organism |
---|---|---|
neutral sphingomyelinase 2 | - |
Homo sapiens |
nSMase2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | decreasing ceramide levels by inhibiting ceramide synthase or neutral sphingomyelinase 2 leads to translocation of membrane-bound aPKC to the cytosol, concurrent with its activation and the phosphorylation of its substrate Aurora kinase A. Ceramide depletion leads to translocation of aPKC from the primary cilium and the apicolateral cell membrane to the cytosol | Homo sapiens |
physiological function | neural differentiation of human embryonic stem cells to neuroprogenitors is concurrent with a threefold elevation of ceramide, in particular, saturated, long-chain C16:0 ceramide (N-palmitoyl sphingosine) and nonsaturated, very long chain C24:1 ceramide (N-nervonoyl sphingosine), involving the enzyme activity, critical role of ceramide generated by nSMase2 in stem cell ciliogenesis and differentiation | Homo sapiens |