Application | Comment | Organism |
---|---|---|
drug development | acid sphingomyelinase activity and sphingomyelin presence are necessary for efficient infection of cells by ebolavirus,the enzym eis a target for drug development | Homo sapiens |
medicine | acid sphingomyelinase activity and sphingomyelin presence are necessary for efficient infection of cells by ebolavirus, inhibition of the enzyme might be a threpeutic way | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amitriptyline | specific inhibitor | Homo sapiens | |
desipramine | specific inhibitor | Homo sapiens | |
imipramine | specific inhibitor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | - |
Homo sapiens | 5768 | - |
lysosome | - |
Homo sapiens | 5764 | - |
plasma membrane | membrane damage or the interaction with some bacterial and viral pathogens can trigger the enzyme's recruitment to the plasma membrane | Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a sphingomyelin + H2O | Homo sapiens | - |
a ceramide + phosphocholine | a ceramide is an N-acylsphingosine | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a sphingomyelin + H2O | - |
Homo sapiens | a ceramide + phosphocholine | a ceramide is an N-acylsphingosine | ? |
Synonyms | Comment | Organism |
---|---|---|
acid sphingomyelinase | - |
Homo sapiens |
aSMase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
acidic pH optimum | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | acid sphingomelin-specific drugs and multiple small interfering RNAs strongly inhibit the infection by ebolavirus and ebolavirus glycoprotein pseudotyped viruses but not by the pseudotypes bearing the glycoprotein of vesicular stomatitis virus, overview. ASMase siRNA-treated cells resist EBOV infection | Homo sapiens |
physiological function | rhinovirus and measles virus each require the enzyme activity during early stages of infection, as well as the ebolavirus. Both sphingomyelin and ceramide are important components of lipid rafts and are potent signaling molecules. Each plays roles in mediating macropinocytosis, which has been shown to be important for ebolavirus infection. The binding of virus-like particles to cells is strongly associated with surface-localized ASMase as well as sphingomyelin-enriched sites, overview | Homo sapiens |