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Literature summary for 3.1.4.12 extracted from

  • Miller, M.E.; Adhikary, S.; Kolokoltsov, A.A.; Davey, R.A.
    Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection (2012), J. Virol., 86, 7473-7483.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development acid sphingomyelinase activity and sphingomyelin presence are necessary for efficient infection of cells by ebolavirus,the enzym eis a target for drug development Homo sapiens
medicine acid sphingomyelinase activity and sphingomyelin presence are necessary for efficient infection of cells by ebolavirus, inhibition of the enzyme might be a threpeutic way Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
amitriptyline specific inhibitor Homo sapiens
desipramine specific inhibitor Homo sapiens
imipramine specific inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
Homo sapiens 5768
-
lysosome
-
Homo sapiens 5764
-
plasma membrane membrane damage or the interaction with some bacterial and viral pathogens can trigger the enzyme's recruitment to the plasma membrane Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a sphingomyelin + H2O Homo sapiens
-
a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a sphingomyelin + H2O
-
Homo sapiens a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Homo sapiens
aSMase
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
acidic pH optimum Homo sapiens

General Information

General Information Comment Organism
malfunction acid sphingomelin-specific drugs and multiple small interfering RNAs strongly inhibit the infection by ebolavirus and ebolavirus glycoprotein pseudotyped viruses but not by the pseudotypes bearing the glycoprotein of vesicular stomatitis virus, overview. ASMase siRNA-treated cells resist EBOV infection Homo sapiens
physiological function rhinovirus and measles virus each require the enzyme activity during early stages of infection, as well as the ebolavirus. Both sphingomyelin and ceramide are important components of lipid rafts and are potent signaling molecules. Each plays roles in mediating macropinocytosis, which has been shown to be important for ebolavirus infection. The binding of virus-like particles to cells is strongly associated with surface-localized ASMase as well as sphingomyelin-enriched sites, overview Homo sapiens